僅用于工業(yè)應用或科學研究，不可用于人類或動物的臨床診斷或治療，非藥用. Dalotuzumab （MK-0646） is a recombinant humanized monoclonal antibody （IgG1 type） targeting IGF-1R. Dalotuzumab acts by inhibiting IGF-1- and IGF-2-mediated tumor cell proliferation, IGF-1R autophosphorylation, and Akt phosphorylation. Dalotuzumab also induces apoptosis and cycle arrest. Dalotuzumab in combination with other anticancer agents such as statins can enhance the antitumor activity of Dalotuzumab in vitro and in vivo